Ontology highlight
ABSTRACT:
SUBMITTER: Nishida Y
PROVIDER: S-EPMC5613972 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nishida Yuya Y Ikeya Teppei T Mikawa Tsutomu T Inoue Jin J Ito Yutaka Y Shintani Yasunori Y Masui Ryoji R Kuramitsu Seiki S Takashima Seiji S
Biochemistry and biophysics reports 20161011
In prokaryotic cells, genomic DNA forms an aggregated structure with various nucleoid-associated proteins (NAPs). The functions of genomic DNA are cooperatively modulated by NAPs, of which HU is considered to be one of the most important. HU binds double-stranded DNA (dsDNA) and serves as a structural modulator in the genome architecture. It plays important roles in diverse DNA functions, including replication, segregation, transcription and repair. Interestingly, it has been reported that HU al ...[more]