Ontology highlight
ABSTRACT:
SUBMITTER: Kamashev D
PROVIDER: S-EPMC2241890 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Kamashev Dmitri D Balandina Anna A Mazur Alexey K AK Arimondo Paola B PB Rouviere-Yaniv Josette J
Nucleic acids research 20071220 3
The nucleoid-associated protein HU plays an important role in bacterial nucleoid organization and is involved in numerous processes including transposition, recombination and DNA repair. We show here that HU binds specifically DNA containing mismatched region longer than 3 bp as well as DNA bulges. HU binds single-stranded DNA (ssDNA) in a binding mode that is reminiscent but different from earlier reported specific HU interactions with double-helical DNA lesions. An HU dimer requires 24 nt of s ...[more]