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Age-related Impairment of Vascular Structure and Functions.


ABSTRACT: Among age-related diseases, cardiovascular and cerebrovascular diseases are major causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age is an independent and essential risk factor. The present work will review morphological alterations of aging vessels in-depth, which includes the discussion of age-related microvessel loss and changes to vasculature involving the capillary basement membrane, intima, media, and adventitia as well as the accompanying vascular dysfunctions arising from these alterations.

SUBMITTER: Xu X 

PROVIDER: S-EPMC5614324 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Age-related Impairment of Vascular Structure and Functions.

Xu Xianglai X   Wang Brian B   Ren Changhong C   Hu Jiangnan J   Greenberg David A DA   Chen Tianxiang T   Xie Liping L   Jin Kunlin K  

Aging and disease 20171001 5


Among age-related diseases, cardiovascular and cerebrovascular diseases are major causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age is an independent and essential risk factor. The present work will review morphological alterations of aging vessels in-depth, which includes the discussion of age-related microvessel loss and changes to vasculature involving the capillary basement membrane, intima, media, and adventitia as well as the accompanying vascular  ...[more]

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