Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5614898 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Li Jun J Dantas Machado Ana Carolina AC Guo Ming M Sagendorf Jared M JM Zhou Zhan Z Jiang Longying L Chen Xiaojuan X Wu Daichao D Qu Lingzhi L Chen Zhuchu Z Chen Lin L Rohs Remo R Chen Yongheng Y
Biochemistry 20170711 29
FOXA2, a member of the forkhead family of transcription factors, plays essential roles in liver development and bile acid homeostasis. In this study, we report a 2.8 Å co-crystal structure of the FOXA2 DNA-binding domain (FOXA2-DBD) bound to a DNA duplex containing a forkhead consensus binding site (GTAAACA). The FOXA2-DBD adopts the canonical winged-helix fold, with helix H3 and wing 1 regions mainly mediating the DNA recognition. Although the wing 2 region was not defined in the structure, iso ...[more]