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A severe myopathy case in aged patient treated with high statin dosage.

ABSTRACT: Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressive medications are required to achieve remission. This case report describes a patient who developed rhabdomyolysis after recent S treatment initiation and the diagnostic work up have lead to the diagnosis of necrotizing autoimmune myopathy (NAM). We believe that the clinical case described here is a useful report of this rare toxicity and we aim to highlight the importance of its prompt recognition and treatment.

SUBMITTER: Canzonieri

PROVIDER: S-EPMC5615159 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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A severe myopathy case in aged patient treated with high statin dosage.

Canzonieri Elena De Candia Cristina C Tarascio Salvatore S Giamporcaro Silvia S Lumera Giovanni G RiganoG iuseppe I Incognito Carmela C Privitera Filippo F Guarnaccia Agata A Foti Pietro Valerio V Palmucci Stefano S Gangemi Pietro P Fuccio-Sanzà Giulia G Signorelli Salvatore Santo SS

Toxicology reports 20170801

Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressive medications are required to achieve remission. This case report describes a patient who developed rhabdomyolysis after recent S treatment initiation and the diagnostic work up have lead to the diagn ...[more]

PMID: 28959671

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Project description:Genetic Susceptibility to Statin-Induced Myopathy

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