Ontology highlight
ABSTRACT:
SUBMITTER: Morris JA
PROVIDER: S-EPMC5615229 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Morris John A JA Tsai Pei-Chien PC Joehanes Roby R Zheng Jie J Trajanoska Katerina K Soerensen Mette M Forgetta Vincenzo V Castillo-Fernandez Juan Edgar JE Frost Morten M Spector Tim D TD Christensen Kaare K Christiansen Lene L Rivadeneira Fernando F Tobias Jonathan H JH Evans David M DM Kiel Douglas P DP Hsu Yi-Hsiang YH Richards J Brent JB Bell Jordana T JT
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20170508 8
Genetic and environmental determinants of skeletal phenotypes such as bone mineral density (BMD) may converge through the epigenome, providing a tool to better understand osteoporosis pathophysiology. Because the epigenetics of BMD have been largely unexplored in humans, we performed an epigenome-wide association study (EWAS) of BMD. We undertook a large-scale BMD EWAS using the Infinium HumanMethylation450 array to measure site-specific DNA methylation in up to 5515 European-descent individuals ...[more]