A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
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ABSTRACT:
SUBMITTER: Jhun MA
PROVIDER: S-EPMC8238961 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
Jhun Min-A MA Mendelson Michael M Wilson Rory R Gondalia Rahul R Joehanes Roby R Salfati Elias E Zhao Xiaoping X Braun Kim Valeska Emilie KVE Do Anh Nguyet AN Hedman Åsa K ÅK Zhang Tao T Carnero-Montoro Elena E Shen Jincheng J Bartz Traci M TM Brody Jennifer A JA Montasser May E ME O'Connell Jeff R JR Yao Chen C Xia Rui R Boerwinkle Eric E Grove Megan M Guan Weihua W Liliane Pfeiffer P Singmann Paula P Müller-Nurasyid Martina M Meitinger Thomas T Gieger Christian C Peters Annette A Zhao Wei W Ware Erin B EB Smith Jennifer A JA Dhana Klodian K van Meurs Joyce J Uitterlinden Andre A Ikram Mohammad Arfan MA Ghanbari Mohsen M Zhi Deugi D Gustafsson Stefan S Lind Lars L Li Shengxu S Sun Dianjianyi D Spector Tim D TD Chen Yii-der Ida YI Damcott Coleen C Shuldiner Alan R AR Absher Devin M DM Horvath Steve S Tsao Philip S PS Kardia Sharon S Psaty Bruce M BM Sotoodehnia Nona N Bell Jordana T JT Ingelsson Erik E Chen Wei W Dehghan Abbas A Arnett Donna K DK Waldenberger Melanie M Hou Lifang L Whitsel Eric A EA Baccarelli Andrea A Levy Daniel D Fornage Myriam M Irvin Marguerite R MR Assimes Themistocles L TL
Nature communications 20210628 1
Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglyc ...[more]
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