Dataset Information

Exposure Modelling of Extremely Low-Frequency Magnetic Fields from Overhead Power Lines and Its Validation by Measurements.

ABSTRACT: A three-dimensional model for calculating long term exposure to extremely low-frequency magnetic fields from high-voltage overhead power lines is presented, as well as its validation by measurements. For the validation, the model was applied to two different high-voltage overhead power lines in Iffwil and Wiler (Switzerland). In order to capture the daily and seasonal variations, each measurement was taken for 48 h and the measurements were carried out six times at each site, at intervals of approximately two months, between January and December 2015. During each measurement, a lateral transect of the magnetic flux density was determined in the middle of a span from nine measurement points in the range of ±80 m. The technical data of both the lines as well as the load flow data during the measurement periods were provided by the grid operators. These data were used to calculate 48 h averages of the absolute value of the magnetic flux density and compared with modelled values. The highest 48 h average was 1.66 µT (centre of the line in Iffwil); the lowest 48 h average was 22 nT (80 m distance from the centre line in Iffwil). On average, the magnetic flux density was overestimated by 2% (standard deviation: 9%) in Iffwil and underestimated by 1% (8%) in Wiler. Sensitivity analyses showed that the uncertainty is mainly driven by errors in the coordinates and height data. In particular, for predictions near the centre of the line, an accurate digital terrain model is critical.

SUBMITTER: Burgi A

PROVIDER: S-EPMC5615486 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Exposure Modelling of Extremely Low-Frequency Magnetic Fields from Overhead Power Lines and Its Validation by Measurements.

Bürgi Alfred A Sagar Sanjay S Struchen Benjamin B Joss Stefan S Röösli Martin M

International journal of environmental research and public health 20170823 9

A three-dimensional model for calculating long term exposure to extremely low-frequency magnetic fields from high-voltage overhead power lines is presented, as well as its validation by measurements. For the validation, the model was applied to two different high-voltage overhead power lines in Iffwil and Wiler (Switzerland). In order to capture the daily and seasonal variations, each measurement was taken for 48 h and the measurements were carried out six times at each site, at intervals of app ...[more]

PMID: 28832515

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Project description:The widespread use of electricity raises the question of whether or not 50 Hz (power line frequency in Europe) magnetic fields (MFs) affect organisms. We investigated the transcription of Escherichia coli K-12 MG1655 in response to extremely low-frequency (ELF) MFs. Fields generated by three signal types (sinusoidal continuous, sinusoidal intermittent, and power line intermittent; all at 50 Hz, 1 mT), were applied and gene expression was monitored at the transcript level using an Affymetrix whole-genome microarray. Bacterial cells were grown continuously in a chemostat (dilution rate D = 0.4 h-1) fed with glucose-limited minimal medium and exposed to 50 Hz MFs with a homogenous flux density of 1 mT. For all three types of MFs investigated, neither bacterial growth (determined using optical density) nor culturable counts were affected. Likewise, no statistically significant change (fold-change > 2, P ≤ 0.01) in the expression of 4,358 genes and 714 intergenic regions represented on the gene chip was detected after MF exposure for 2.5 h (1.4 generations) or 15 h (8.7 generations). Moreover, short-term exposure (8 min) to the sinusoidal continuous and power line intermittent signal neither affected bacterial growth nor showed evidence for reliable changes in transcription. In conclusion, our experiments did not indicate that the different tested MFs (50 Hz, 1 mT) affected the transcription of E. coli. A total of 60 chips are included in this study. Each comparison (treated vs. sham-treated cultures; untreated negative control cultures) consists of three replicates. The three magnetic field test conditions include sinusoidal continous, sinusoidal intermittent (2 min on, 4 min off) and power line intermittent (2 min on, 4 min off). Exposure periods were 8 min, 2.5 h, or 15 h. The response control consists of E. coli cells treated for 10 min with 1 mM H2O2 or the equivalent water volume. The negative control comprises samples taken from cultures grown with the exposure chambers swiched off.

Project description:The formation of new blood vessels is an essential therapeutic target in many diseases such as cancer, ischemic diseases, and chronic inflammation. In this regard, extremely low-frequency (ELF) electromagnetic fields (EMFs) seem able to inhibit vessel growth when used in a specific window of amplitude. To investigate the mechanism of anti-angiogenic action of ELF-EMFs we tested the effect of a sinusoidal magnetic field (MF) of 2 mT intensity and frequency of 50 Hz on endothelial cell models HUVEC and MS-1 measuring cell status and proliferation, motility and tubule formation ability. MS-1 cells when injected in mice determined a rapid tumor-like growth that was significantly reduced in mice inoculated with MF-exposed cells. In particular, histological analysis of tumors derived from mice inoculated with MF-exposed MS-1 cells indicated a reduction of hemangioma size, of blood-filled spaces, and in hemorrhage. In parallel, in vitro proliferation of MS-1 treated with MF was significantly inhibited. We also found that the MF-exposure down-regulated the process of proliferation, migration and formation of tubule-like structures in HUVECs. Using western blotting and immunofluorescence analysis, we collected data about the possible influence of MF on the signalling pathway activated by the vascular endothelial growth factor (VEGF). In particular, MF exposure significantly reduced the expression and activation levels of VEGFR2, suggesting a direct or indirect influence of MF on VEGF receptors placed on cellular membrane. In conclusion MF reduced, in vitro and in vivo, the ability of endothelial cells to form new vessels, most probably affecting VEGF signal transduction pathway that was less responsive to activation. These findings could not only explain the mechanism of anti-angiogenic action exerted by MFs, but also promote the possible development of new therapeutic applications for treatment of those diseases where excessive angiogenesis is involved.

Dataset Information

Exposure Modelling of Extremely Low-Frequency Magnetic Fields from Overhead Power Lines and Its Validation by Measurements.

Publications

Exposure Modelling of Extremely Low-Frequency Magnetic Fields from Overhead Power Lines and Its Validation by Measurements.

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