Ontology highlight
ABSTRACT:
SUBMITTER: George JT
PROVIDER: S-EPMC5617294 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
George Jason T JT Kessler David A DA Levine Herbert H
Proceedings of the National Academy of Sciences of the United States of America 20170905 38
The advent of cancer immunotherapy has generated renewed hope for the treatment of many malignancies by introducing a number of novel strategies that exploit various properties of the immune system. These therapies are based on the idea that cytotoxic T lymphocytes (CTLs) directly recognize and respond to tumor-associated neoantigens (TANs) in much the same way as they would to foreign peptides presented on cell surfaces. To date, however, nearly all attempts to optimize immunotherapeutic strate ...[more]