?? T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.

ABSTRACT: Major histocompatibility complex (MHC) restriction is the cardinal feature of T cell antigen recognition and is thought to be intrinsic to ?? T cell receptor (TCR) structure because of germline-encoded residues that impose MHC specificity. Here, we analyzed ??TCRs from T cells that had not undergone MHC-specific thymic selection. Instead of recognizing peptide-MHC complexes, the two ??TCRs studied here resembled antibodies in recognizing glycosylation-dependent conformational epitopes on a native self-protein, CD155, and they did so with high affinity independently of MHC molecules. Ligand recognition was via the ??TCR combining site and involved the identical germline-encoded residues that have been thought to uniquely impose MHC specificity, demonstrating that these residues do not only promote MHC binding. This study demonstrates that, without MHC-specific thymic selection, ??TCRs can resemble antibodies in recognizing conformational epitopes on MHC-independent ligands.

SUBMITTER: Tikhonova AN 

PROVIDER: S-EPMC3268851 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature