Identification and causes of metabonomic difference between orthotopic and subcutaneous xenograft of pancreatic cancer.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumors. However, the methodological differences between orthotopic and subcutaneous xenograft (OX and SX) models will cause confusion in understanding its pathological mechanism and clinical relevance. In this study, SX and OX models were established by implanting Panc-1 and BxPC-3 cell strains under skin and on the pancreas of mice, respectively. The tumor tissue and serum samples were collected for¹H NMR spectroscopy followed by univariate and multivariate statistical analyses. As results, no obvious metabonomic difference was demonstrated in serum between the two models, however, the model- and cell strain-specific metabonomic differences were observed in tumor tissues. According to the KEGG analysis, ABC trans

SUBMITTER: Zhan B 

PROVIDER: S-EPMC5617422 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature