Ontology highlight
ABSTRACT:
SUBMITTER: Liu T
PROVIDER: S-EPMC5617424 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Liu Ting T Gulinaer Abulajiang A Shi Xiaoli X Wang Feng F An Hengqing H Cui Wenli W Li Qiaoxin Q
Oncotarget 20170522 37
In this hospital-based case-control study of 413 prostate cancer (PCa) cases and 807 cancer-free controls, we investigated the role of functional single nucleotide polymorphisms (SNPs) of pivotal genes in the PI3K/AKT/mTOR pathway. We genotyped 17 SNPs in <i>mTOR</i>, <i>Raptor, AKT1</i>, <i>AKT2</i>, <i>PTEN</i>, and <i>K-ras</i> and found that 4 were associated with PCa susceptibility. Among the variants, the homozygote variant CC genotype of <i>mTOR</i> rs17036508 C>T were associated with hig ...[more]