Ontology highlight
ABSTRACT:
SUBMITTER: Heng S
PROVIDER: S-EPMC5618042 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Heng Sabrina S Zhang Xiaozhou X Pei Jinxin J Abell Andrew D AD
Biosensors 20170906 3
γ-Glutamyl-cysteinyl-glycine (GSH) plays a critical role in maintaining redox homeostasis in biological systems and a decrease in its cellular levels is associated with diseases. Existing fluorescence-based chemosensors for GSH acts as irreversible reaction-based probes that exhibit a maximum fluorescence ('turn-on') once the reaction is complete, regardless of the actual concentration of GSH. A reversible, reaction-based 'turn-off' probe ( <b>1</b> ) is reported here to sense the decreasin ...[more]