Ontology highlight
ABSTRACT:
SUBMITTER: Heng S
PROVIDER: S-EPMC6044982 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Heng Sabrina S Reineck Philipp P Vidanapathirana Achini K AK Pullen Benjamin J BJ Drumm Daniel W DW Ritter Lesley J LJ Schwarz Nisha N Bonder Claudine S CS Psaltis Peter J PJ Thompson Jeremy G JG Gibson Brant C BC Nicholls Stephen J SJ Abell Andrew D AD
ACS omega 20170927 9
Biologically compatible fluorescent ion sensors, particularly those that are reversible, represent a key tool for answering a range of fundamental biological questions. We report a rationally designed probe with a 6'-fluoro spiropyran scaffold (<b>5</b>) for the reversible sensing of zinc (Zn<sup>2+</sup>) in cells. The 6'-fluoro substituent overcomes several limitations normally associated with spiropyran-based sensors to provide an improved signal-to-background ratio and faster photoswitching ...[more]