Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC5618547 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Liu Hongliang H Wei Qing Q Huang Chenyang C Zhang Yong Y Guo Zekun Z
International journal of molecular sciences 20170904 9
DNA methylation is an important epigenetic modification that needs to be carefully controlled as a prerequisite for normal early embryogenesis. Compelling evidence now suggests that four maternal-effect proteins, primordial germ cell 7 (PGC7), zinc finger protein 57 (ZFP57), tripartite motif-containing 28 (TRIM28) and DNA methyltransferase (cytosine-5) 1 (DNMT1) are involved in the maintenance of DNA methylation. However, it is still not fully understood how these maternal-effect proteins mainta ...[more]