Ontology highlight
ABSTRACT:
SUBMITTER: Karlic H
PROVIDER: S-EPMC5618631 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Karlic Heidrun H Haider Florian F Thaler Roman R Spitzer Silvia S Klaushofer Klaus K Varga Franz F
International journal of molecular sciences 20170915 9
Statins and bisphosphonates are increasingly recognized as anti-cancer drugs, especially because of their cholesterol-lowering properties. However, these drugs act differently on various types of cancers. Thus, the aim of this study was to compare the effects of statins and bisphosphonates on the metabolism (NADP⁺/NADPH-relation) of highly proliferative tumor cell lines from different origins (PC-3 prostate carcinoma, MDA-MB-231 breast cancer, U-2 OS osteosarcoma) versus cells with a slower prol ...[more]