Ontology highlight
ABSTRACT:
SUBMITTER: Hato T
PROVIDER: S-EPMC5619018 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Immunotherapy 20160211 3
Hepatocellular carcinoma (HCC) is a fatal disease with rising incidence in the world. For advanced HCC, sorafenib, a multikinase inhibitor, is the only systemic therapy with proven survival benefits. Sorafenib is a pan-VEGF receptor inhibitor, and thus many studies have focused its antivascular effects. But VEGF also acts as an immunosuppressive molecule. VEGF can inhibit maturation of dendritic cells, promote immune suppressive cell infiltration and enhance immune checkpoint molecules expressio ...[more]