Ontology highlight
ABSTRACT:
SUBMITTER: Shoben AB
PROVIDER: S-EPMC5620018 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Shoben Abigail B AB Rudser Kyle D KD Emerson Scott S SS
Journal of biopharmaceutical statistics 20160406 1
Statistical intuition suggests that increasing the total number of observations available for analysis should increase the precision with which parameters can be estimated. Such monotonic growth of statistical information is of particular importance when data are analyzed sequentially, such as in confirmatory clinical trials. However, monotonic information growth is not always guaranteed, even when using a valid, but inefficient estimator. In this article, we demonstrate the theoretical possibil ...[more]