Ontology highlight
ABSTRACT:
SUBMITTER: Yan H
PROVIDER: S-EPMC5620130 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170329 14
We report a new strategy to regulate microRNAs (miRNAs) biogenesis by using bifunctional small molecules that consist of a pre-miRNA binding unit connected by a linker to a Dicer inhibiting unit. In this effort, fluorescence polarization-based screening was used to identify neomycin as a pre-miR-21 binding ligand. Although neomycin cannot inhibit miR-21 maturation, linking it to the RNase inhibitor 1 forms the bifunctional conjugate 7A, which inhibits the production of miR-21. We expect that thi ...[more]