Ontology highlight
ABSTRACT:
SUBMITTER: Meng L
PROVIDER: S-EPMC5216115 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Meng Lingyu L Liu Cuicui C Lü Jinhui J Zhao Qian Q Deng Shengqiong S Wang Guangxue G Qiao Jing J Zhang Chuyi C Zhen Lixiao L Lu Ying Y Li Wenshu W Zhang Yuzhen Y Pestell Richard G RG Fan Huiming H Chen Yi-Han YH Liu Zhongmin Z Yu Zuoren Z
Nature communications 20170103
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with high affinity, high specificity and high stability. Two miRNAs, miR-221 and miR-17, are tested in human breast cancer cell lines, demonstrating the 70∼90% knockdown of miRNA levels by ...[more]