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Effects of roniciclib in preclinical models of anaplastic thyroid cancer.

ABSTRACT: Many human cancers have altered cyclin-dependent kinase activity. Inhibition of cyclin-dependent kinases may arrest cell cycle progression and represents an important strategy in the treatment of malignancies. We evaluated the therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor, as a treatment for anaplastic thyroid cancer. Roniciclib inhibited anaplastic thyroid cancer cell proliferation in a dose-dependent manner. Roniciclib activated caspase-3 activity and induced apoptosis. Cell cycle progression was arrested in G2/M phase. In vivo, the growth of anaplastic thyroid cancer xenograft tumors was retarded by roniciclib treatment without evidence of toxicity. These data provide a rationale for further clinical evaluation using roniciclib in the treatment of patients with anaplastic thyroid cancer.

SUBMITTER: Lin SF

PROVIDER: S-EPMC5620230 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Effects of roniciclib in preclinical models of anaplastic thyroid cancer.

Lin Shu-Fu SF Lin Jen-Der JD Hsueh Chuen C Chou Ting-Chao TC Wong Richard J RJ

Oncotarget 20170708 40

Many human cancers have altered cyclin-dependent kinase activity. Inhibition of cyclin-dependent kinases may arrest cell cycle progression and represents an important strategy in the treatment of malignancies. We evaluated the therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor, as a treatment for anaplastic thyroid cancer. Roniciclib inhibited anaplastic thyroid cancer cell proliferation in a dose-dependent manner. Roniciclib activated caspase-3 activity and induced apoptosis ...[more]

PMID: 28978090

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