Ontology highlight
ABSTRACT:
SUBMITTER: Lin SF
PROVIDER: S-EPMC6021325 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Lin Shu-Fu SF Lin Jen-Der JD Hsueh Chuen C Chou Ting-Chao TC Wong Richard J RJ
Oncotarget 20180615 46
Altered cyclin-dependent kinase activity is observed in many human malignancies. Cyclin-dependent kinases that promote cell cycle progression may be promising targets in the treatment of cancer. The therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor for medullary thyroid cancer were investigated in the present study. Roniciclib inhibited medullary thyroid cancer cell proliferation in a dose-dependent manner. Roniciclib induced caspase-3 activity and contributed to apoptosis. ...[more]