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Polymer nanodiscs and macro-nanodiscs of a varying lipid composition.

ABSTRACT: Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to ?60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties.

SUBMITTER: Ramadugu VSK

PROVIDER: S-EPMC5621649 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Polymer nanodiscs and macro-nanodiscs of a varying lipid composition.

Ramadugu Venkata Sudheer Kumar VSK Di Mauro Giacomo Maria GM Ravula Thirupathi T Ramamoorthy Ayyalusamy A

Chemical communications (Cambridge, England) 20170901 78

Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to ∼60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties. ...[more]

PMID: 28926036

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