Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh AK
PROVIDER: S-EPMC5621746 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ghosh Arun K AK Nyalapatla Prasanth R PR
Tetrahedron 20170217 14
The total syntheses of (-)-amphirionin-4 and (+)-amphirionin-4 have been achieved in a convergent and enantioselective manner. The tetrahydrofuranol cores of amphirionin-4 were constructed in optically active form by enzymatic resolution of racemic <i>cis</i>-3-hydroxy-5-methyldihydrofuran-2(3<i>H</i>)-one. The polyene side chain was efficiently synthesized using Stille coupling. The remote C8-stereocenter was constructed using the Nozaki-Hiyama-Kishi coupling reaction. A detailed <sup>1</sup>H- ...[more]