Ontology highlight
ABSTRACT:
SUBMITTER: Karasawa A
PROVIDER: S-EPMC5621764 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Karasawa Akira A Kawate Toshimitsu T
Bio-protocol 20170901 17
The P2X7 receptor is an extracellular ATP-gated ion channel found only in eukaryotes (Bartlett <i>et al</i>., 2014). Due to its unique properties among P2X receptors, such as formation of a large conductance pore, the P2X7 receptor has been implicated in devastating diseases like chronic pain (North and Jarvis, 2013). However, mechanisms underlying the P2X7 specific properties remain poorly understood, partly because purification of this eukaryotic membrane protein has been challenging. Here we ...[more]