Ontology highlight
ABSTRACT:
SUBMITTER: Gaurav R
PROVIDER: S-EPMC5621928 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Gaurav Rohit R Varasteh Jason T JT Weaver Michael R MR Jacobson Sean R SR Hernandez-Lagunas Laura L Liu Qing Q Nozik-Grayck Eva E Chu Hong Wei HW Alam Rafeul R Nordestgaard Børge G BG Kobylecki Camilla J CJ Afzal Shoaib S Chupp Geoffrey L GL Bowler Russell P RP
JCI insight 20170907 17
Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) is the major antioxidant in lungs, but its role in allergic asthma is unknown. Here we report that asthmatics have increased SOD3 transcript levels in sputum and that a single nucleotide polymorphism (SNP) in SOD3 (R213G; rs1799895) changes lung distribution of EC-SOD, and decreases likelihood of asthma-related symptoms. Knockin mice analogous to the human R213G SNP had lower a ...[more]