Ontology highlight
ABSTRACT:
SUBMITTER: Garcia AM
PROVIDER: S-EPMC6172610 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Physiological genomics 20180713 9
Extracellular superoxide dismutase (EC-SOD), one of three mammalian SOD isoforms, is the sole extracellular enzymatic defense against superoxide. A known human single nucleotide polymorphism (SNP) in the matrix-binding domain of EC-SOD characterized by an arginine-to-glycine substitution at position 213 (R213G) redistributes EC-SOD from the matrix into extracellular fluids. We previously reported that knock-in mice harboring the human R213G SNP (R213G mice) exhibited enhanced resolution of infla ...[more]