Systemic corticosteroids improve tendon healing when given after the early inflammatory phase.
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ABSTRACT:
SUBMITTER: Blomgran P
PROVIDER: S-EPMC5622078 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Systemic corticosteroids improve tendon healing when given after the early inflammatory phase.
Blomgran Parmis P Hammerman Malin M Aspenberg Per P
Scientific reports 20170929 1
Inflammation initiates tendon healing and then normally resolves more or less completely. Unresolved inflammation might disturb the remodeling process. We hypothesized that suppression of inflammation during the early remodeling phase by systemic dexamethasone treatment can improve healing. 36 rats underwent Achilles tendon transection and were randomized to dexamethasone or saline on days 0-4 after surgery (early inflammatory phase), and euthanasia day 7. Another 54 rats received injections day ...[more]
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