Ontology highlight
ABSTRACT:
SUBMITTER: Hauser DN
PROVIDER: S-EPMC5622528 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Hauser David N DN Mamais Adamantios A Conti Melissa M MM Primiani Christopher T CT Kumaran Ravindran R Dillman Allissa A AA Langston Rebekah G RG Beilina Alexandra A Garcia Joseph H JH Diaz-Ruiz Alberto A Bernier Michel M Fiesel Fabienne C FC Hou Xu X Springer Wolfdieter W Li Yan Y de Cabo Rafael R Cookson Mark R MR
Molecular neurodegeneration 20170929 1
<h4>Background</h4>Early onset Parkinson's disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but the function of DJ-1 and how it relates to PINK1 and parkin is poorly understood.<h4>Methods</h4>A series of unbiased high-content screens were used to analyze changes at the protein, RNA, and metabolite level in rodent brains lacking DJ-1. Results were validated using targeted approaches, and cellular assays were per ...[more]