Ontology highlight
ABSTRACT:
SUBMITTER: Bolton Moore C
PROVIDER: S-EPMC5623109 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Bolton Moore Carolyn C Capparelli Edmund V EV Samson Pearl P Bwakura-Dangarembizi Mutsa M Jean-Philippe Patrick P Worrell Carol C Heckman Barbara B Purdue Lynette L Spector Stephen A SA Benns Alex A Borkowsky William W Loftis Amy A Hawkins Elizabeth E Wallis Carole C Chadwick Ellen G EG
AIDS (London, England) 20170501 8
<h4>Objectives</h4>To determine safety-specific, efficacy-specific and genotypic-specific dose requirements of efavirenz (EFV) in children aged 3 to less than 36 months with HIV infection.<h4>Design</h4>IMPAACT P1070 was a 24-week prospective cohort trial of EFV (as open capsules) and two nucleoside reverse transcriptase inhibitors in children with HIV infection 3 to less than 36 months without tuberculosis (Cohort 1).<h4>Methods</h4>CYP2B6 G516T genotype was determined, and intensive pharmacoki ...[more]