Ontology highlight
ABSTRACT:
SUBMITTER: Metzger IF
PROVIDER: S-EPMC6853154 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Metzger Ingrid F IF Dave Nimita N Kreutz Yvonne Y Lu Jessica B L JBL Galinsky Raymond E RE Desta Zeruesenay Z
Clinical and translational science 20190812 6
We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N-acetyltransferase 2 (NAT2), using caffeine as a probe. A single 150 mg oral dose of caffeine was administered to healthy volunteers (n = 58) on two separate occasions; with a single 600 mg oral dose of efavirenz and after treatment with 600 mg/day efavirenz for 17 days. Caffeine and its metabolites in plasma and urine were quantified using liquid chromatography/tandem-mass ...[more]