Dataset Information

Relationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon.

ABSTRACT:

Objectives

Cardiovascular disease (CVD) and metabolic diseases are growing concerns among patients with HIV infection as a consequence of the improving survival of this population. We aimed to assess the relationship between CVD risk and insulin resistance in a group of black African individuals with HIV infection.

Methods

This cross-sectional study involved patients with HIV infection aged 30-74 years and followed up at the Yaoundé Central Hospital, Cameroon. Absolute CVD risk was calculated using the Framingham and the DAD CVD risk equations while the HOMA-IR index was used to assess insulin resistance (index ?2.1).

Results

A total of 452 patients (361 women; 80%) were screened. The mean age was 44.4 years and most of the respondents were on antiretroviral therapy (88.5%). The median 5-year cardiovascular risk was 0.7% (25th-75th percentiles: 0.2-2.0) and 0.6% (0.3-1.3) according to the Framingham and DAD equations respectively. Of all participants, 47.3% were insulin resistant. The Framingham equation derived absolute CVD risk was significantly associated with insulin resistance; while no linear association was found using the DAD equation.

Conclusion

The relationship between cardiovascular risk and insulin resistance in black African patients with HIV infection seems to depend on the cardiovascular risk equation used.

SUBMITTER: Noumegni SR

PROVIDER: S-EPMC5623432 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Publications

Relationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon.

Noumegni Steve Raoul SR Bigna Jean Joel JJ Ama Moor Epse Nkegoum Vicky Jocelyne VJ Nansseu Jobert Richie JR Assah Felix K FK Jingi Ahmadou Musa AM Guewo-Fokeng Magellan M Leumi Steve S Katte Jean-Claude JC Dehayem Mesmin Y MY Mfeukeu Kuate Liliane L Kengne Andre Pascal AP Sobngwi Eugene E

BMJ open 20170811 8

<h4>Objectives</h4>Cardiovascular disease (CVD) and metabolic diseases are growing concerns among patients with HIV infection as a consequence of the improving survival of this population. We aimed to assess the relationship between CVD risk and insulin resistance in a group of black African individuals with HIV infection.<h4>Methods</h4>This cross-sectional study involved patients with HIV infection aged 30-74 years and followed up at the Yaoundé Central Hospital, Cameroon. Absolute CVD risk wa ...[more]

PMID: 28801428

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Dataset Information

Relationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon.

Objectives

Methods

Results

Conclusion

Publications

Relationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon.

Similar Datasets

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