Dataset Information

Association of vascular access flow with short-term and long-term mortality in chronic haemodialysis patients: a retrospective cohort study.

ABSTRACT:

Objectives

To investigate the impact of vascular access flow (Qa) on vascular and all-cause mortality in chronic haemodialysis (HD) patients.

Design

Observational cohort study.

Setting

Single centre.

Participants

Adult chronic HD patients at the HD unit of Shin Kong Wu Ho-Su Memorial Hospital between 1 January 2003 and 31 December 2003 were recruited. Patients were excluded if they had arteriovenous fistula or arteriovenous graft failure within 3 months before the date of Qa measurement, were aged <18 years and had Qa levels of ?2000mL/min. A total of 378 adult chronic HD patients were eventually enrolled for the study.

Interventions

The selected patients were evaluated with Qa and cardiac index (CI). They were divided into four groups according to three Qa cut-off points (500, 1000 and 1500?mL/min).

Primary and secondary outcome measures

Short-term and long-term vascular (cardiovascular or cerebrovascular) and all-cause mortality.

Results

Qa was positively correlated with CI (r=0.48, p<0.001). A Qa level of <1000?mL/min was independently associated with 1-year all-cause mortality (adjusted OR, 6.04; 95% CI 1.64 to 22.16; p=0.007). Kaplan-Meier analysis revealed that the cumulative incidence rates of all-cause and vascular mortality were significantly higher in the patients with a Qa level of <1000?mL/min (log-rank test; all p<0.01). Furthermore, a Qa level of <1000?mL/min was independently associated with long-term all-cause mortality (adjusted HR, 1.62; 95% CI 1.11 to 2.37; p=0.013); however, the risk of vascular mortality did not significantly increase after adjustment for confounders.

Conclusions

Qa is moderately correlated with cardiac function, and a Qa level of <1000?mL/min is an independent risk factor for both short-term and long-term all-cause mortality in chronic HD patients.

SUBMITTER: Wu CK

PROVIDER: S-EPMC5623550 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of vascular access flow with short-term and long-term mortality in chronic haemodialysis patients: a retrospective cohort study.

Wu Chung-Kuan CK Wu Chia-Lin CL Lin Chia-Hsun CH Leu Jyh-Gang JG Kor Chew-Teng CT Tarng Der-Cherng DC

BMJ open 20170924 9

<h4>Objectives</h4>To investigate the impact of vascular access flow (Qa) on vascular and all-cause mortality in chronic haemodialysis (HD) patients.<h4>Design</h4>Observational cohort study.<h4>Setting</h4>Single centre.<h4>Participants</h4>Adult chronic HD patients at the HD unit of Shin Kong Wu Ho-Su Memorial Hospital between 1 January 2003 and 31 December 2003 were recruited. Patients were excluded if they had arteriovenous fistula or arteriovenous graft failure within 3 months before the da ...[more]

PMID: 28947453

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Dataset Information

Association of vascular access flow with short-term and long-term mortality in chronic haemodialysis patients: a retrospective cohort study.

Objectives

Design

Setting

Participants

Interventions

Primary and secondary outcome measures

Results

Conclusions

Publications

Association of vascular access flow with short-term and long-term mortality in chronic haemodialysis patients: a retrospective cohort study.

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