Dataset Information

Thiazide diuretics and the risk of hip fracture after stroke: a population-based propensity-matched cohort study using Taiwan's National Health Insurance Research Database.

ABSTRACT:

Objectives

This study aimed to investigate the association between thiazide use and the risk of hip fracture after stroke.

Setting

A population-based, propensity-matched cohort study was conducted on the basis of Taiwan's National Health Insurance Research Database.

Participants

Patients with newly diagnosed ischaemic stroke between 2000 and 2011 were included. After propensity score matching, 7470 patients were included, of whom 3735 received thiazides and 3735 did not.

Outcome measures

HRs for developing hip fractures within 2?years after stroke were calculated using Cox proportional hazards regression model with adjustments for sociodemographic and coexisting medical conditions.

Results

Overall, patients using thiazides after stroke had a lower risk of hip fracture than those not using thiazides (8.5 vs 13.9 per 1000 person-years, adjusted HR=0.64, 95%?CI 0.46 to 0.89, p=0.007). Further sensitivity analysis based on the duration of thiazide use revealed that the risk of hip fracture tended to decrease as the duration of exposure of thiazides increased. However, the effect was significant only in patients with long-term use of thiazides (using thiazides for >365?days within 2?years after stroke), with a 59% reduction in the risk of hip fracture when compared with patients not using thiazide (adjusted HR=0.41, 95%?CI 0.22 to 0.79, p=0.008).

Conclusions

The long-term use of thiazides is associated with a decreased risk of hip fracture after stroke.

SUBMITTER: Lin SM

PROVIDER: S-EPMC5623561 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Thiazide diuretics and the risk of hip fracture after stroke: a population-based propensity-matched cohort study using Taiwan's National Health Insurance Research Database.

Lin Shu-Man SM Yang Shih-Hsien SH Cheng Hung-Yu HY Liang Chung-Chao CC Huang Huei-Kai HK

BMJ open 20170927 9

<h4>Objectives</h4>This study aimed to investigate the association between thiazide use and the risk of hip fracture after stroke.<h4>Setting</h4>A population-based, propensity-matched cohort study was conducted on the basis of Taiwan's National Health Insurance Research Database.<h4>Participants</h4>Patients with newly diagnosed ischaemic stroke between 2000 and 2011 were included. After propensity score matching, 7470 patients were included, of whom 3735 received thiazides and 3735 did not.<h4 ...[more]

PMID: 28963293

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Dataset Information

Thiazide diuretics and the risk of hip fracture after stroke: a population-based propensity-matched cohort study using Taiwan's National Health Insurance Research Database.

Objectives

Setting

Participants

Outcome measures

Results

Conclusions

Publications

Thiazide diuretics and the risk of hip fracture after stroke: a population-based propensity-matched cohort study using Taiwan's National Health Insurance Research Database.

Similar Datasets

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