Ontology highlight
ABSTRACT:
SUBMITTER: Chung SS
PROVIDER: S-EPMC5624309 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Science translational medicine 20170101 374
Acute myeloid leukemia (AML) and the myelodysplastic syndromes (MDS) are initiated and sustained by self-renewing malignant stem cells; thus, eradication of AML and MDS stem cells is required for cure. We identified CD99 as a cell surface protein frequently overexpressed on AML and MDS stem cells. Expression of CD99 allows for prospective separation of leukemic stem cells (LSCs) from functionally normal hematopoietic stem cells in AML, and high CD99 expression on AML blasts enriches for function ...[more]