Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies.
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ABSTRACT:
SUBMITTER: Sonbol MB
PROVIDER: S-EPMC6466109 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies.
Sonbol Mohamad B MB Ahn Daniel H DH Bekaii-Saab Tanios T
Biomedicines 20190310 1
Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maint ...[more]
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