Complete Genome Sequences of Human Immunodeficiency Type 1 Viruses Genetically Engineered To Be Tropic for Rhesus Macaques.
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ABSTRACT:
SUBMITTER: Nomaguchi M
PROVIDER: S-EPMC5624769 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Complete Genome Sequences of Human Immunodeficiency Type 1 Viruses Genetically Engineered To Be Tropic for Rhesus Macaques.
Nomaguchi Masako M Doi Naoya N Koma Takaaki T Adachi Akio A
Genome announcements 20170928 39
We have constructed two human immunodeficiency type 1 (HIV-1) derivatives, CXCR4 tropic and CCR5 tropic, that replicate in rhesus macaques. They are genetically engineered to be resistant to macaque restriction factors against HIV-1, including TRIM5α, APOBEC3, and tetherin proteins. The two HIV-1 variants described here are fundamental clones aiming for rhesus infection studies of HIV-1. ...[more]
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