Flex-nucleoside analogues - Novel therapeutics against filoviruses.
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ABSTRACT:
SUBMITTER: Yates MK
PROVIDER: S-EPMC5626011 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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Flex-nucleoside analogues - Novel therapeutics against filoviruses.
Yates Mary K MK Raje Mithun R MR Chatterjee Payel P Spiropoulou Christina F CF Bavari Sina S Flint Mike M Soloveva Veronica V Seley-Radtke Katherine L KL
Bioorganic & medicinal chemistry letters 20170422 12
Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC<sub>50</sub>=2μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC<sub>50</sub> of 7μM. ...[more]
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