Ontology highlight
ABSTRACT:
SUBMITTER: Rojas M
PROVIDER: S-EPMC5626372 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rojas Macarena M Díaz Pablo P León Pablo P Gonzalez Alexis A AA González Magdalena M Barrientos Víctor V Pestov Nikolay B NB Alzamora Rodrigo R Michea Luis L
Channels (Austin, Tex.) 20170621 5
Renal sodium reabsorption depends on the activity of the Na<sup>+</sup>,K<sup>+</sup>-ATPase α/β heterodimer. Four α (α<sub>1-4</sub>) and 3 β (β<sub>1-3</sub>) subunit isoforms have been described. It is accepted that renal tubule cells express α<sub>1</sub>/β<sub>1</sub> dimers. Aldosterone stimulates Na<sup>+</sup>,K<sup>+</sup>-ATPase activity and may modulate α<sub>1</sub>/β<sub>1</sub> expression. However, some studies suggest the presence of β<sub>3</sub> in the kidney. We hypothesized th ...[more]