Ontology highlight
ABSTRACT:
SUBMITTER: Wei Y
PROVIDER: S-EPMC5626417 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wei Yuping Y Ma Liang L Zhang Liang L Xu Xia X
International journal of nanomedicine 20170925
An effective drug delivery system requires efficient drug uptake and release inside cancer cells. Here, we report a novel drug delivery system, in which paclitaxel (PTX) interacts with a novel cell penetrating peptide (CPP) through noncovalent interaction designed based on molecular simulations. This CPP/PTX complex confers high efficiency in delivering PTX into cancer cells not by endocytosis but by an energy-independent pathway. Once inside cells, the noncovalent interaction between PTX and th ...[more]