Ontology highlight
ABSTRACT:
SUBMITTER: Huynh W
PROVIDER: S-EPMC5626548 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Huynh Walter W Vale Ronald D RD
The Journal of cell biology 20170907 10
Bicaudal D2 (BICD2) joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement. Point mutations in the <i>BICD2</i> gene have been identified in patients with a dominant form of spinal muscular atrophy, but how these mutations cause disease is unknown. To investigate this question, we have developed in vitro motility assays with purified DDB and BICD2's membrane vesicle partner, the GTPase Rab6a. Rab6a-GTP, either in solution or bound to artificial liposomes, r ...[more]