Ontology highlight
ABSTRACT:
SUBMITTER: Saxena M
PROVIDER: S-EPMC5626599 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Saxena Mansi M Bhardwaj Nina N
Current opinion in immunology 20170718
Development of therapeutic cancer vaccines has been hindered by the many pro-tumorigenic mechanisms at play in cancer patients that serve to suppress both antigen presenting cells and T cells. In face of these obstacles, cancer vaccines are most likely to promote anti-tumorigenic immune responses only when formulated with strong adjuvants, and in combination with new immune interventions designed to reverse immune suppression and exhaustion of T cells in the tumor microenvironment. Dendritic cel ...[more]