Ontology highlight
ABSTRACT:
SUBMITTER: Bainor AJ
PROVIDER: S-EPMC5626631 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bainor Anthony J AJ Deng Fang-Ming FM Wang Yu Y Lee Peng P Cantor David J DJ Logan Susan K SK David Gregory G
Cancer research 20170814 19
Distinguishing between indolent and aggressive prostate adenocarcinoma remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence <i>in vitro</i> Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive prostate adenocarcinoma. Furthermore, SIN3B was downregulated in huma ...[more]