Ontology highlight
ABSTRACT:
SUBMITTER: Rielland M
PROVIDER: S-EPMC4001548 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Rielland Maïté M Cantor David J DJ Graveline Richard R Hajdu Cristina C Mara Lisa L Diaz Beatriz de Diego Bde D Miller George G David Gregory G
The Journal of clinical investigation 20140401 5
Pancreatic ductal adenocarcinoma (PDAC) is strikingly resistant to conventional therapeutic approaches. We previously demonstrated that the histone deacetylase-associated protein SIN3B is essential for oncogene-induced senescence in cultured cells. Here, using a mouse model of pancreatic cancer, we have demonstrated that SIN3B is required for activated KRAS-induced senescence in vivo. Surprisingly, impaired senescence as the result of genetic inactivation of Sin3B was associated with delayed PDA ...[more]