Ontology highlight
ABSTRACT:
SUBMITTER: Serpooshan V
PROVIDER: S-EPMC5626718 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Serpooshan Vahid V Liu Yuan-Hung YH Buikema Jan W JW Galdos Francisco X FX Chirikian Orlando O Paige Sharon S Venkatraman Sneha S Kumar Anusha A Rawnsley David R DR Huang Xiaojing X Pijnappels Daniël A DA Wu Sean M SM
Scientific reports 20171003 1
During normal lifespan, the mammalian heart undergoes limited renewal of cardiomyocytes. While the exact mechanism for this renewal remains unclear, two possibilities have been proposed: differentiated myocyte replication and progenitor/immature cell differentiation. This study aimed to characterize a population of cardiomyocyte precursors in the neonatal heart and to determine their requirement for cardiac development. By tracking the expression of an embryonic Nkx2.5 cardiac enhancer, we ident ...[more]