Ontology highlight
ABSTRACT:
SUBMITTER: Zamir L
PROVIDER: S-EPMC5400512 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zamir Lyad L Singh Reena R Nathan Elisha E Patrick Ralph R Yifa Oren O Yahalom-Ronen Yfat Y Arraf Alaa A AA Schultheiss Thomas M TM Suo Shengbao S Han Jing-Dong Jackie JJ Peng Guangdun G Jing Naihe N Wang Yuliang Y Palpant Nathan N Tam Patrick Pl PP Harvey Richard P RP Tzahor Eldad E
eLife 20170308
Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and live imaging in avian embryos, and genetic lineage tracing in mice, we investigated the spatio-temporal dynamics of cardiovascular progenitor populations. We show that expression of the cardiac transcription factor <i>Nkx2.5</i> marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, ...[more]