Ontology highlight
ABSTRACT:
SUBMITTER: Hou X
PROVIDER: S-EPMC5626782 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Hou Xubin X Yoshioka Nozomu N Tsukano Hiroaki H Sakai Akiko A Miyata Shinji S Watanabe Yumi Y Yanagawa Yuchio Y Sakimura Kenji K Takeuchi Kosei K Kitagawa Hiroshi H Hensch Takao K TK Shibuki Katsuei K Igarashi Michihiro M Sugiyama Sayaka S
Scientific reports 20171003 1
Ocular dominance plasticity is easily observed during the critical period in early postnatal life. Chondroitin sulfate (CS) is the most abundant component in extracellular structures called perineuronal nets (PNNs), which surround parvalbumin-expressing interneurons (PV-cells). CS accumulates in PNNs at the critical period, but its function in earlier life is unclear. Here, we show that initiation of ocular dominance plasticity was impaired with reduced CS, using mice lacking a key CS-synthesizi ...[more]