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Beta Trace Protein does not outperform Creatinine and Cystatin C in estimating Glomerular Filtration Rate in Older Adults.


ABSTRACT: Despite intense research the optimal endogenous biomarker for glomerular filtration rate (GFR) estimation has not been identified yet. We analyzed if ß-trace protein (BTP) improved GFR estimation in elderly. 566 participants aged 70+ from the population-based Berlin Initiative Study were included in a cross-sectional validation study. BTP, standardized creatinine and cystatin C were measured in participants with iohexol clearance measurement as gold standard method for measured GFR (mGFR). In a double logarithmic linear model prediction of mGFR by BTP was assessed. Analyses with BTP only and combined with creatinine and cystatin C were performed. Additionally, performance of GFR estimating equations was compared to mGFR. We found that the combination of all three biomarkers showed the best prediction of mGFR (r2?=?0.83), whereat the combination of creatinine and cystatin C provided only minimally diverging results (r2?=?0.82). Single usage of BTP showed worst prediction (r2?=?0.67) within models with only one biomarker. Subgroup analyses (arterial hypertension, diabetes, body mass index ?23 and >30) demonstrated a slight additional benefit of including BTP into the prediction model for diabetic, hypertensive and lean patients. Among BTP-containing GFR equations the Inker BTP-based equation showed superior performance. Especially the use of cystatin C renders the addition of BTP unnecessary.

SUBMITTER: Ebert N 

PROVIDER: S-EPMC5627233 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Beta Trace Protein does not outperform Creatinine and Cystatin C in estimating Glomerular Filtration Rate in Older Adults.

Ebert Natalie N   Koep Camilla C   Schwarz Kristin K   Martus Peter P   Mielke Nina N   Bartel Jan J   Kuhlmann Martin M   Gaedeke Jens J   Toelle Markus M   van der Giet Markus M   Schuchardt Mirjam M   Schaeffner Elke E  

Scientific reports 20171004 1


Despite intense research the optimal endogenous biomarker for glomerular filtration rate (GFR) estimation has not been identified yet. We analyzed if ß-trace protein (BTP) improved GFR estimation in elderly. 566 participants aged 70+ from the population-based Berlin Initiative Study were included in a cross-sectional validation study. BTP, standardized creatinine and cystatin C were measured in participants with iohexol clearance measurement as gold standard method for measured GFR (mGFR). In a  ...[more]

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