Unknown

Dataset Information

0

Enantioselective semireduction of allenes.


ABSTRACT: Rh-hydride catalysis solves a synthetic challenge by affording the enantioselective reduction of allenes, thereby yielding access to motifs commonly used in medicinal chemistry. A designer Josiphos ligand promotes the generation of chiral benzylic isomers, when combined with a Hantzsch ester as the reductant. This semireduction proceeds chemoselectively in the presence of other functional groups, which are typically reduced using conventional hydrogenations. Isotopic labelling studies support a mechanism where the hydride is delivered to the branched position of a Rh-allyl intermediate.Reduction of allenes poses several challenges in terms of chemo-, regio- and enantio-selectivity. Here, the authors report a rhodium-Josiphos catalytic system that reduces a variety of aryl allenes to chiral benzylic compounds with excellent selectivity and functional group tolerance.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5627242 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Enantioselective semireduction of allenes.

Chen Zhiwei Z   Dong Vy M VM  

Nature communications 20171004 1


Rh-hydride catalysis solves a synthetic challenge by affording the enantioselective reduction of allenes, thereby yielding access to motifs commonly used in medicinal chemistry. A designer Josiphos ligand promotes the generation of chiral benzylic isomers, when combined with a Hantzsch ester as the reductant. This semireduction proceeds chemoselectively in the presence of other functional groups, which are typically reduced using conventional hydrogenations. Isotopic labelling studies support a  ...[more]

Similar Datasets

| S-EPMC5615263 | biostudies-literature
| S-EPMC6173636 | biostudies-literature
| S-EPMC6355870 | biostudies-other
| S-EPMC5716636 | biostudies-literature
| S-EPMC3169097 | biostudies-literature
| S-EPMC9442582 | biostudies-literature
| S-EPMC6748664 | biostudies-literature
| S-EPMC5821421 | biostudies-literature
| S-EPMC4715695 | biostudies-literature
| S-EPMC6369434 | biostudies-literature