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Light-responsive paper strips as CO-releasing material with a colourimetric response.


ABSTRACT: Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC50 ? 30 ?M). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye.

SUBMITTER: Reddy G U 

PROVIDER: S-EPMC5627354 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Light-responsive paper strips as CO-releasing material with a colourimetric response.

Reddy G Upendar U   Liu Jingjing J   Hoffmann Patrick P   Steinmetzer Johannes J   Görls Helmar H   Kupfer Stephan S   Askes Sven H C SHC   Neugebauer Ute U   Gräfe Stefanie S   Schiller Alexander A  

Chemical science 20170726 9


Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (<b>CORM-Dabsyl</b>) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (<b>L</b>). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media,  ...[more]

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